Archive | January 2014

Sjogren’s Syndrome Causes, Symptoms, Treatment, Dignosis

Sjogren’s syndrome is the second most common systemic autoimmune disorder characterized by dry eyes and dry mouth. Autoantibodies are created against the moisture-secreting glands which affect the mucous membranes and glands of the eyes and mouth leading to inadequate tear film production and deficiency of salivary secretions respectively. A person suffering from sjogren’s syndrome might also have lupus or rheumatoid arthritis. Inflammation of the glands and other tissues of the body occur as a result of defective immune system making antibodies against these glands. It more commonly occurs in women but men can also be affected. Although it can occur at any age but most patients are above the 40 years.

Sicca Syndrome:

Sicca syndrome an autoimmune infection, otherwise called Sjogren that traditionally joins dry eyes, dry mouth, and another sickness of connective tissue, for example, rheumatoid joint pain, lupus, scleroderma or polymyositis. There is a tremendous prevalence of women. Approximately 90% of Sicca Syndrome patients is woman, generally in middle age or more experienced?

Dry Eyes Syndrome:

Dry Eyes Syndrome and dry mouth are the most widely recognized side effects.

SJOGREN’S SYNDROME CAUSES:

Sjogren’s syndrome is believed to occur as a result of familial genetic tendency. This form is called primary sjogren’s syndrome. Faulty gene transmission from parent to offspring constitute as a principal sjogren’s syndrome causes. In families having other autoimmune connective tissues diseases like lupus erythematosus, schleroderma or rheumatoid arthritis, the chance of developing sjogren’s syndrome is about 90% in women. When it is associated with these disorders then it is termed as secondary sjogren’s syndrome. A certain environmental agent such as infection from a particular virus or a bacterial strain acts as a triggering agent for the syndrome.

SJOGREN’S SYNDROME SYMPTOMS:

As a result of damage to moisture-secreting glands in eyes and mouth, two prominent symptoms of the syndrome, dry eyes and dry mouth are evident. Dry eyes manifest as keratoconjucntivitis sicca i.e implaying faulty tear film along with burning, gritting and itching of eyes. Other sjogren’s syndrome symptoms include difficulty in speaking and swallowing as a result of dry mouth. It may also affect other organs of the body such as lungs, liver, pancreas, kidney, blood vessels and brain. Dryness of nose, skin and vagina is also seen. Joint pain, swollen salivary gland, persistent dry cough and prolonged fatigues are important symptom seen in such patients.

SJOGREN’S SYNDROME COMPLICATION:

In a pregnant female with sjogren’s syndrome, the child may be born with congenital heart block or neonatal lupus erythematosus. A well-known sjogren’s syndrome’s complication is type 1 cytoglobulinemia.

SJOGREN’S SYNDROME DIAGNOSIS:

Blood tests are performed in other to measure the antibody titer for sjogren’s syndrome diagnosis. Anti-nuclear antibodies and rheumatoid factor are the two most important diagnostic antibodies found in sjogren’s syndrome. Production of tears is measured by schirmer’s test. Slit-examinations, radiological studies and biopsy is also carried out.

Dry Mouth Treatment:

On the off possibility that you think your dry mouth is bring about by certain medicine you are taking, converse with your specialist. He or she may alter the dimension you are taking or change you to an alternate medication that doesn’t bring about Dry Mouth Treatment.

SJOGREN’S SYNDROME TREATMENT:

There is no specific treatment or cure present for sjogren’s syndrome. However the condition is manageable and is controlled symptom wise.  For dry eyes, artificial tears are prescribed. Punctual plugs and goggles are also prescribed to increase humidity and retain the tears on eye surface for long time. Immunosuppressive drugs or corticosteroids are also prescribed but are associated with a large amount of side-effects. In the presence of musculoskeletal involvement, NSAIDs are used. Sjogren’s syndrome herbal product derived from pure herbal plant extracts also proved to be very effective in controlling and treating of sjogren’s syndrome. The drug has so side-effect and currently the best sjogren’s syndrome treatment option available.

Causes of Porphyria, Symptoms, Diagnosis, Treatment of Porphyria

Porphyria, a rare disorder involving certain enzymes in the body required for the production of heme pigment and porphyrins. It may be inherited or acquired. It is derived from a Greek word which means ‘purple pigment’ owing to discoloration of urine and feces when exposed to light during the attack. Two type of porphyria disease are present, which are cutaneous and acute. Cutaneous is associated with the skin involvement while acute produces neurological complications. These porphyrias may sometimes be present together simultaneously in the same person.

Porphyria cutanea tarda:

Porphyria cutanea tarda (PCT) is a term encompassing a collection of acquired and familial disorders in which movement of the heme synthetic enzyme uroporphyrinogen decarboxylase (UROD) is deficient.

Acute intermittent porphyria:

Acute intermittent porphyria (AIP) is an uncommon autosomal dominant [1] metabolic disease affecting the creation of heme, the oxygen-binding prosthetic collection of hemoglobin.

CAUSES OF PORPHYRIA:

Porphyrias of at least eight different types exist owing to defect in different enzymes of the body responsible for heme production. Heme is an important iron containing pigment present in erythrocytes responsible for the transport and delivery of oxygen to different organs and tissues. Series of eight different steps involving different enzyme in each step, are responsible for normal production of heme in liver and bone marrow. Defect or deficiency of these enzymes disrupts the process leading to abnormal accumulation of large amount of porphyrins in the body. Porphyria Causes include inherited or acquired mutation in one or more genes. Most common pattern is transmission of faulty gene from parents to offspring. Acquired mutations result from a number of environmental factors. These include alcohol abuse, dieting and fasting, cigarette smoking and drugs such as sedatives, birth controls, transquilizers and barbiturates. Long term exposure to sunlight, hormones, chemicals, stress, excessive dietary iron intake and infections with HBV also trigger the mutations.

PORPHYRIA SYMPTOMS:

Porphyria symptoms depend upon its type. Erythropoietic or cutaneous porphyria is the type which is associated with skin disorders especially when exposed to sun. Skin may swell, blisters form, photodermitis, darkening and thickening of skin along with increased hair growth on forehead is seen. In acute or hepatic type of porphyria, neurological symptoms result. The onset is abrupt and last for several days or week. Due to faulty electrolyte balance, signs and symptoms of increased blood pressure, heart rate, severe abdominal pain, back, limb and chest pain along with tingling, vomiting, numbness, seizures, psychosis, agitation and confusion are found.  Urine on exposure to the sun, changes color to dark brown or dark red owing to the presence and oxidation of abnormal constituents (heme precursors) present in it in different forms of porphyria.

PORPHYRIA DIAGNOSIS:

Porphyria diagnosis is based upon the biochemical findings and analysis of patient’s urine, stool and blood. Porphobilinogen level in urine is elevated in case of acute porphyria.

PORPHYRIA TREATMENT:

In case of acute fatal attack, patient should be hospitalized immediately and treatment should be initiated. No complete cure is present but symptomatic management of the condition prevents the disease progression. Analgesics and anti-emetics are prescribed for pain and vomiting. In porphyria treatment, patient is advised to eat carbohydrate enriched diet. In acute type, treatment with heme arginate and hematin is prescribed. For long term cimetidine is prescribed as prophylactic. Porphyria herbal product made up of rich herbs and plants cure the condition proficiently without any side effects which are normally present with allopathic medications. Herbal mixture improves the condition within a short period of time by curing all the symptoms of the disease.

Polycythemia Vera Treatment, Causes, Symptoms, Diagnosis

Polycythemia vera is a type of myelopoliferative blood disorder characterized by the excessive formation of red blood cells (erythrocytes) by the bone marrow. White blood cells and platelet count also increases. It is a rare bone marrow disorder. Primary disease manifestation lies in the thickening of blood caused by too many red blood cells in the circulation which might lead to clot formation. Clot formation causes the blockage of arteries and veins ultimately leading to fatal stroke or a heart attack. Due to increase density of blood in the vessels, the flow becomes slow and sluggish preventing adequate oxygen from reaching the tissues especially heart hence angina or heart failure results.

POLYCYTHEMIA VERA CAUSES: 

It affects all age group although incidence rises with age. It occurs more commonly in men than women. Polycythemia vera causes is associated with the genetic mutation of an important gene called JAK2V617F. The exact cause of mutation is not known. A single faulty haematopoietic precursor cell in bone marrow leads to clonal expansion resulting in polycythemia vera. The sensitivity of erythroid precursors to erythropoietin increases causing large production of red blood cell formation.

Polycythemia Rubra Vera:

Polycythaemia Rubra Vera, also called essential polycythaemia Vera, is an problem where an excess of red cells are produced in the bone marrow, with no certain cause.

Polycythemia Vera life expectancy:

Polycythemia Vera life expectancy may be bargained as the infection develops to myelofibrosis, or seldom, intense leukemia.

POLYCYTHEMIA VERA SYMPTOMS:

The disease is slow and progressive usually requiring the period of about 4 to 5 years before it presents itself. Characteristic signs and polycythemia vera symptoms include increased mass of erythrocytes (RBCs), neutrophilia (increased neutrophils than normal), thrombocytosis (increased platelet count in blood) and splenomegaly (enlargement of spleen). Severe burning and itching of hands and feet is found due to histamine release. Increased viscosity of blood is responsible for the following symptoms: history of vascular occlusive disease, dizziness, headache, gout, pruritus, mental confusion, flushed face and abdominal discomfort. Due to abnormalities of RBCs and platelet, symptoms of epistaxis, thromboembolism, gum bleeding and gastrointestinal bleeding is common.

POLYCYTHEMIA VERA COMPLICATIONS:

Other than stroke and heart attack being a fatal polycythemia vera complications, a small group of sufferers progressively develop malignant blood disorders of acute myelogenous leukemia or myelofibrosis.

POLYCYTHEMIA VERA DIAGNOSIS:

Prognosis of the disease is strongly influenced by early diagnosis and treatment. Blood tests are performed to find out the count of cells. Complete blood picture and erythrocyte-sedimentation rate reveal and confirm the polycythemia vera diagnosis. Physical examination reveals enlarged spleen or liver and in some cases gouty nodules.

POLYCYTHEMIA VERA TREATMENT:

Polycythemia vera treatment is based upon reducing the symptoms of the disease because no specific cure is present for it. Timely management is necessary otherwise it may prove fatal. Phlebotomy is performed to remove blood from the body thus reducing the viscosity of blood associated with increased volume. Aspirin is also prescribed to prevent clot formation. Chemotherapy is indicated for its treatment but it is associated with increased risk of developing acute myelogenous leukemia. Radioactive isotopic injections, although suppress bone marrow, can also lead to AML malignant transformation. Polycythemia vera herbal product cures the condition effectively owing to the presence of its herbal constituents which help the body to restore and maintain its normal physiological functions by completely treating the disease and its associated symptoms in a short span of time.

Emphysema Causes, Symptoms, Diagnosis, Treatment

What Is Emphysema? is a type of chronic obstructive pulmonary disease characterized by destruction of air-sacs (alveoli) of the lungs leading to shortness of breath. In emphysema alveoli become filled with air which expand with time, eventually break and get replaced by scar tissue formation. These alveoli form an important part of blood-lung oxygen exchange system. Damaged to these air-sacs therefore causes progressive shortness of breath in the patients.

SURGICAL EMPHYSEMA:

Surgical emphysema occurs while air/gas is situated in the subcutaneous tissues. This generally occurs in the chest, face or neck.

BULLOUS EMPHYSEMA:

Bullous emphysema is recognized as vanishing lung condition too. Emphysema causes a loss of elasticity in the walls of the little air sacs in the lung.

EMPHYSEMA CAUSES:

The most important world-wide emphysema causes is cigarette smoking. Long term regular tobacco smoking has deleterious effects on body. Lungs are most commonly damaged. Passive smoking is regarded more dangerous than active smoking. Chances of emphysema increase in terms of total smoke exposure. Other emphysema causes includes air pollution, occupational exposure to harmful chemicals, fuels and gases. Cooking without proper ventilation can also lead to it. Surface area of the lung is greatly reduced due to conversion of alveoli into large irregular air-filled pockets with holes in them caused by the harmful smokes. Genetics is also involved in the disease’s progression. Some eminent causes of emphysema are aging, environmental factors and reduced airway reactivity.

EMPHYSEMA SYMPTOMS:

Emphysema symptoms are related to alveolar damage and loss. Initially no symptoms appear except asthma during exersions. With the passage of time patient experiences shortness of breath even at rest owing to destruction of alveoli causing less amount of oxygen entering the blood. In chronic cases, patient presents with cough with or without sputum, fatigue, recurrent infections of lung, arrhythmia, need for oxygen therapy, severe weight loss, malnutrition and thinning of bones. Right side of the heart is adversely affected by chronic lung disease leading to a condition called cor pulmonale. Elastic fibers holding small air ways are also destroyed leading to collapse of airways while exhaling causing entrapping of air within the lungs. Wheezing sounds can be heard by the clinician on examination of chest through stethoscope.

EMPHYSEMA DIAGNOSIS:

Emphysema diagnosis is based upon its symptoms of shortness of breath, chronic cough with sputum, history of exposure to risk factors and frequent infections in patients over the age of 35 to 40 years. Confirmation of diagnosis is then done on the basis of results obtained by spirometry. FEV1/ FVC ratio of less than 0.7 after bronchodilator use confirms emphysema. Complete blood count and X-ray chest are also important diagnostic tools for emphysema.

EMPHYSEMA TREATMENT:

Emphysema can’t be completely cured when the destruction and loss of alveoli occurs. However it can be effectively managed through the control of risk factors and supplementary treatments through oxygen ventilation therapies. Emphysema treatment options include use of inhalation bronchodilators in order to open up the collapse air passages during asthmic attacks. They are associated with side-effects of urinary tract abnormalities and dry mouth. Corticosteroids are also used to reduce acute exacerbations. Supplemental oxygen therapy and lung transplant surgeries are also indicated in chronic advanced cases. Overall prognosis of the disease is poor. Emphysema herbal product, containing pure herbal extracts, effectively treats symptoms of emphysema without any side effects. With herbal product usage, amazing recovery has been observed in emphysema patients within short span of time.

Granuloma Annulare Causes, Symptoms, Diagnosis, Treatment

Granuloma annulare is a chronic autoimmune dermatological disorder characterized by papules in the form of reddish bumps forming a ring shape appearance. These reddish bumps are commonly present on hands, feet, knees and elbows. This benign inflammatory condition of annular plaques on the skin is caused by an autoimmune response causing increased production of white blood cells (leukocytosis).

GRANULOMA ANNULARE CAUSES:

The exact cause of this condition is still not identified but some doctors associate this condition with thyroid disorders and diabetes mellitus. The patient seems overall healthy and no other organ or system is affected. The large amount of white blood cells circulating in the blood have some difficulty in running smoothly and thus leak through the thin capillary network to reach the undersurface of the skin, clumping there and presenting themselves as circular reddish bumps on the surface of the skin. Among granuloma annulare causes, association with some other autoimmune disorders is identified such as lupus erythematosis, addison’s disease and rheumatoid arthritis. It may also occur as a result of hypersensitivity to wheat gluten, tetanus vaccine or copper and infections along with animal, insect bites and sunlight exposure.

GRANULOMA ANNULARE SYMPTOMS:

This condition is more common in females than males. It affects individual in all age groups however relatively rare in infants. Granuloma annulare symptoms begin in the form of small pimple like bump which advances rapidly to large and large sized lesions. Patient notices the appearance of thickened plaques, red in color, firm in consistency on the surface of forearms, hands and feet. There may be multiple rings which merge to form a large single annular plaque. It may present in four different varieties: localized, generalized, subcutaneous and perforating. It may sometimes also present on the circumference of the waist and sides and continues for years without any therapy.

GRANULOMA ANNULARE DIAGNOSIS:

Granuloma annulare diagnosis is based upon the physical examination of the bumps by a skin doctor. Biopsy can be performed in order to comfirm the diagnosis or differentiate the condition from other skin disorders and malignancies.

GRANULOMA ANNULARE TREATMENT:

In most cases treatment of granuloma annulare is not needed because these lesions have the tendency of spontaneous resolution within a period of few months to few years. However the process of self-healing can be quickened by the adequate treatment options. Granuloma annulare treatment includes corticosteroids creams and ointments, adhesive patches or bandages for improved rapid results, direct injection of corticosteroids in the papules, liquid nitrogen cryotherapy to remove the lesion and replacement of it by new normal skin, laser and light therapy or excision of the lesion. All these are associated with side-effects and post-surgical pain. Oral medications are prescribed to prevent reactions of immune system. Granuloma annulare herbal product is effective in timely removal of these lesions without any side-effects and pain as seen with allopathic medications and surgical procedure. The herbal mixture improves the overall appearance of skin, leaving it smooth and soft along with completely curing this ailment in no time.

Treatment of Peripheral Neuropathy, Causes, Symptoms

What Is Peripheral neuropathy is a medical disorder in which the nerve fibers of peripheral nervous system are affected. Peripheral nerves are normally concerned with carrying signals and sensations to and from the brain and spinal cord to the entire body. Vast numbers of factors are responsible for affecting nerves such as toxin exposure, recurrent infections, trauma to the nerves or as a side-effect of some chronic systemic disease such as diabetes mellitus. Weakness, loss of consciousness and numbness are common symptoms experienced by the patient along with sweltering pain. Motor, sensory or autonomic nerves, any one of them can be affected with patient losing control of areas supplied by these nerve groups.

Diabetic peripheral neuropathy:

Diabetic peripheral neuropathy is a long-term problem of diabetes. Exposure to high blood glucose levels over an comprehensive period of occasion causes injure to the peripheral nerves.

PERIPHERAL NEUROPATHY CAUSES:

A large number of factors are included in peripheral neuropathy causes. Chronic alcohol abusers suffer from this condition due to vitamin deficiency states resulting from their poor unhealthy dietary habits. Sjogren’s syndrome, rheumatoid arthritis, lupus, chronic demyelinating neuropathies, vasculitis are autoimmune disorders in which peripheral neuropathy is a common symptom. If multiple nerves are involved, condition is usually attributed to have occurred secondary to diabetes mellitus. Heavy metal toxicity associated with their inhalation or ingestion leads to peripheral neuropathies. Trauma, severe infections, accidents and drugs like flouroquinolones can also cause peripheral neuropathy.

SYMPTOMS OF PERIPHERAL NEUROPATHY:

Symptoms of peripheral neuropathy depend upon the affected nerves. All nerves in a group affecting some part of the body, several nerves affecting the entire body or sometimes just one nerve is damaged. Burning and tingling kind of pain in extremeties such as hands and toes is most common sign present in patients with peripheral neuropathies. Numbness prevents some patients from appreciating pain on contact with hot, cold or some sharp object. Muscular weakness, shrinkage and atrophy result from lack of usage due to damage to the nerve supplying it. Person trips while walking, has abnormal gait and even unable to finish easy everyday tasks like buttoning his shirt. Buckling of legs causes the patient to fall. Food digestion, sweating, micturition and sexual problems occur in some patients with peripheral neuropathy.

TREATMENT OF PERIPHERAL NEUROPATHY:

Peripheral neuropathy treatment is based upon treating the underlying cause responsible for damaging the nerve or nerve group. Sugar level is monitored and controlled through medications in diabetic patients. Vitamins supplements and proper diet chart is prescribed to patient. Regular exercises, for improving the muscle control and strength are employed. Anti-depressants and anti-epileptic agents are given to control neuropathic pain. Early diagnosis is associated with better prognosis. Aids such as sticks, crutches and wheel chairs are used by patients in order to come over the problems with normal walking. Peripheral neuropathy herbal product prevents the patient from going through such type of mental and physical dependence by treating the condition effectively in short span of time owing to its complex curative herbal mixture that relieves the pain and treats the underlying cause.