Polycythemia Vera is a myeloproliferative blood disorder characterized by the excessive formation of red blood cells (erythrocytes) by the bone marrow. White blood cells and platelet count also increases. It is a rare bone marrow disorder. Primary disease manifestation lies in the thickening of blood caused by too many red blood cells in the circulation which might lead to clot formation. Clot formation causes the blockage of arteries and veins ultimately leading to a fatal stroke or a heart attack. Because of the increased density of blood in the vessels, the flow becomes slow and sluggish preventing adequate oxygen from reaching the tissues especially heart hence angina or heart failure results.
POLYCYTHEMIA VERA CAUSES
It affects all age groups, although incidence rises with age. It occurs more commonly in men than in women. Polycythemia Vera Causes is associated with the genetic mutation of an important gene called JAK2V617F. The exact cause of the mutation is not known. A single fault haematopoietic precursor cell in bone marrow leads to clonal expansion resulting in Polycythemia Vera. The sensitivity of erythroid precursors to erythropoietin increases, causing large production of red blood cell formation.
Polycythemia Rubra Vera, also called essential polycythaemia Vera, is a problem where an excess of red cells is produced in the bone marrow, with no certain cause.
Polycythemia Vera life expectancy
Polycythemia Vera life expectancy may be bargained as the infection develops to myelofibrosis, or seldom, intense leukaemia.
POLYCYTHEMIA VERA SYMPTOMS
The disease is slow and progressive, usually requiring a period of about 4 to 5 years before it presents itself. Characteristic signs and Polycythemia Vera Symptoms include the increased mass of erythrocytes (RBCs), neutrophilia (increased neutrophils than normal), thrombocytosis (increased platelet count in the blood) and splenomegaly (enlargement of the spleen). Severe burning and itching of hands and feet are found because of histamine release. Increased viscosity of blood is responsible for the following symptoms: a history of the vascular occlusive disease, dizziness, headache, gout, pruritus, mental confusion, flushed face and abdominal discomfort. Due to abnormalities of RBCs and platelet, symptoms of epistaxis, thromboembolism, gum bleeding and gastrointestinal bleeding is common.
POLYCYTHEMIA VERA COMPLICATIONS
Other than stroke and Heart Attack being a fatal polycythemia vera complication, a small group of sufferers progressively develop malignant blood disorders of acute myelogenous leukaemia or myelofibrosis.
POLYCYTHEMIA VERA DIAGNOSIS
Prognosis of the disease is strongly influenced by early diagnosis and treatment. Blood tests are performed to find out the count of cells. Complete blood picture and erythrocyte-sedimentation rate reveal and confirm the polycythemia vera diagnosis. Physical examination reveals enlarged spleen or liver and sometimes gouty nodules.
POLYCYTHEMIA VERA Herbal TREATMENT
Polycythemia Vera Herbal Treatment is based upon reducing the symptoms of the disease because no specific cure is present for it. Timely management is necessary, otherwise, it may prove fatal. Phlebotomy is performed to remove blood from the body, thus reducing the viscosity of blood associated with increased volume. Aspirin is also prescribed to prevent clot formation. Chemotherapy is indicated for its treatment but it is associated with the increased risk of developing acute myelogenous leukaemia. Radioactive isotopic injections, although suppress the bone marrow, can also lead to AML malignant transformation. Polycythemia vera herbal product cures the condition owing to its herbal constituents, which help the body restore and maintain its normal physiological functions by Natural Remedies For Polycythemia Vera and its associated symptoms in a short time.