Inclusion body myositis is a progressive inflammatory myopathy characterized mainly by proximal limb weakness, diminished deep tendon reflexes, dysphagia and mixed neurogenic and myopathic changes. Clinically it manifests itself as progressive muscle weakness and wasting. The onset is gradual usually over months or years ending up in a sever disability. Characteristic tubo-filamentous inclusions are present within the cytoplasm and nuclei of myocytes. It is most common in people above the age of 50 years.
Inclusion body myositis epidomology:
The mortality rate of the disease is hard to access as it occurs in old patients who die of other co-existing medical condition. Males are affected three times more than females. The prognosis of disease is rather poor as condition continues to deteriorate and the stabilization, if seen, is mostly temporary rather than permanent.
Inclusion body myositis causes:
Inclusion body myositis causes are multifactorial. It have been established that aging plays an important role while pathogenomic effects of environmental antigens such as viral antigen which might induce an autoimmune response is still in question. Studies support the idea of excessive accumulation of certain proteins as the cause of the disease. These proteins evoke inflammatory process by causing autoimmune reaction. Defect in human leukocyte antigen genes is also suspected.
Inclusion body myositis symptoms:
Asymmetrical weakness of the muscles of neck, hip, back, shoulder, wrist and fingers is the primary presenting symptom. This weakness in the thighs may cause sudden falling, in lower leg may cause difficult foot lifting and in pharynx may cause dysphagia. Weakened muscles also predispose to injuries affecting bones joints and other soft tissues. Fatigue and cardiac disease are also inclusion body myositis symptoms.
Inclusion body myositis diagnosis:
It is done on the bases of clinical features and lab tests. Lab tests will show high levels of creatine kinase and different pattern of muscle contraction on Blood CP and Electromyography respectively. However biopsy is the only definitive diagnostic test.
Inclusion body myositis differential diagnosis:
The clinical picture of inclusion body myositis can resemble to several other conditions from which it need to be differentiated it includes dermatomyositis and polymyositis, oculopharyngeal dystrophy, chronic atrophic sarcoid myopathy, myasthenia gravis and motor neuron disease.
Inclusion body myositis treatment:
Currently no successful inclusion body myositis treatment is available however inclusion body myositis herbal product has miraculous effects on the prognosis of disease. This herbal product if taken with physical therapy, occupational therapy and ergo therapy, positive improvements in the patient’s condition can be easily seen.