Granuloma annulare- type 1 hypersensitivity reaction

What is granuloma annulare?

Benign inflammatory condition, effecting skin, characterized by formation of papules and annular plaques is known as what is granuloma annulare. Histologicaly degenerative collagen with granulomatous inflammation is present. The exact cause is not yet understood completely but the condition can be associated with diabetes or any other systemic diseases. There are five clinical variants of this condition which includes localized, generalized, subcutaneous, perforating and acute dermal erythema. This condition is managed by the use of granuloma annulare herbal product by natural herbs clinic.

Granuloma annulare epidemiology:

this is a relatively uncommon condition with localized type effecting most of the people. On the other hand perforating and annular erythema are the uncommon types. Females are affected more than men with localized type more common in adults as compared to other kinds.

Granuloma annulare symptoms:

the granuloma annulare symptoms and signs vary. The localized form is characterized by a broad circular or a semicircular shaped lesion with up to 2 inch diameter on hands, wrists, feet and ankles as observed by experts at natural herbs clinic. In generalized form of disease large portion of the body is affected such as arms, legs or trunk along with itching and tenderness. Subcutaneous granuloma annulare on the other hand is characterized by firm, subcutaneous lumps which are less than one inch in diameter. The overlying layer of dermis in such cases is normal.

Granuloma annulare causes:

the granuloma annulare causes is not specified yet but certain things are known to trigger the condition. This includes insect bites, viral infections, skin test done for the diagnosis of tuberculosis, vaccinations and sometimes sun exposure. In case of generalized lesions, the condition is also associated with autoimmune thyroiditis and diabetes.

Granuloma annulare diagnosis:

the granuloma annulare diagnosis can be easily done on the basis of clinical examination of the lesion. If the diagnosis is in doubt, examination of small skin sample under the microscope is done. This is known as biopsy. The experts at natural herbs clinic observed that the early lesion will have lymphocytes, macrophages and mucin with visible hyaluronic acid, embedded between the collagen fiber bundles while in a fully evolved lesion macrophages encircling nicrobiotic areas with thinned collagen bundles are visible. On the other hand deeply esinophilic central area containing degenerated collagen is a characteristic of subcutaneous granuloma annulare.

Granuloma annulare treatment:

spontaneous remission is seen in several cases of granuloma annulare but rest of the lesions need treatment. Corticosteriod creams, ointments, injections and oral tablets are recommended along with cryotherapy and light therapy ofr granuloma annulare treatment. The corticosteroids use is associated with several side effects while both cryotherapy and light therapy are invasive procedures and should be done only in extreme conditions. Granuloma annulare herbal product by natural herbs clinic is the best treatment available for the management of this condition. It is a formula prepared by using 100% natural herbs so is very effective and is free of any side effects.

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