Granuloma annulare- type 1 hypersensitivity reaction

What is granuloma annulare?

Benign inflammatory condition, effecting skin, characterized by formation of papules and annular plaques is known as what is granuloma annulare. Histologicaly degenerative collagen with granulomatous inflammation is present. The exact cause is not yet understood completely but the condition can be associated with diabetes or any other systemic diseases. There are five clinical variants of this condition which includes localized, generalized, subcutaneous, perforating and acute dermal erythema. This condition is managed by the use of granuloma annulare herbal product by natural herbs clinic.

Granuloma annulare epidemiology:

this is a relatively uncommon condition with localized type effecting most of the people. On the other hand perforating and annular erythema are the uncommon types. Females are affected more than men with localized type more common in adults as compared to other kinds.

Granuloma annulare symptoms:

the granuloma annulare symptoms and signs vary. The localized form is characterized by a broad circular or a semicircular shaped lesion with up to 2 inch diameter on hands, wrists, feet and ankles as observed by experts at natural herbs clinic. In generalized form of disease large portion of the body is affected such as arms, legs or trunk along with itching and tenderness. Subcutaneous granuloma annulare on the other hand is characterized by firm, subcutaneous lumps which are less than one inch in diameter. The overlying layer of dermis in such cases is normal.

Granuloma annulare causes:

the granuloma annulare causes is not specified yet but certain things are known to trigger the condition. This includes insect bites, viral infections, skin test done for the diagnosis of tuberculosis, vaccinations and sometimes sun exposure. In case of generalized lesions, the condition is also associated with autoimmune thyroiditis and diabetes.

Granuloma annulare diagnosis:

the granuloma annulare diagnosis can be easily done on the basis of clinical examination of the lesion. If the diagnosis is in doubt, examination of small skin sample under the microscope is done. This is known as biopsy. The experts at natural herbs clinic observed that the early lesion will have lymphocytes, macrophages and mucin with visible hyaluronic acid, embedded between the collagen fiber bundles while in a fully evolved lesion macrophages encircling nicrobiotic areas with thinned collagen bundles are visible. On the other hand deeply esinophilic central area containing degenerated collagen is a characteristic of subcutaneous granuloma annulare.

Granuloma annulare treatment:

spontaneous remission is seen in several cases of granuloma annulare but rest of the lesions need treatment. Corticosteriod creams, ointments, injections and oral tablets are recommended along with cryotherapy and light therapy ofr granuloma annulare treatment. The corticosteroids use is associated with several side effects while both cryotherapy and light therapy are invasive procedures and should be done only in extreme conditions. Granuloma annulare herbal product by natural herbs clinic is the best treatment available for the management of this condition. It is a formula prepared by using 100% natural herbs so is very effective and is free of any side effects.


Granuloma Annulare Causes, Symptoms, Diagnosis, Treatment

Granuloma annulare is a chronic autoimmune dermatological disorder characterized by papules in the form of reddish bumps forming a ring shape appearance. These reddish bumps are commonly present on hands, feet, knees and elbows. This benign inflammatory condition of annular plaques on the skin is caused by an autoimmune response causing increased production of white blood cells (leukocytosis).


The exact cause of this condition is still not identified but some doctors associate this condition with thyroid disorders and diabetes mellitus. The patient seems overall healthy and no other organ or system is affected. The large amount of white blood cells circulating in the blood have some difficulty in running smoothly and thus leak through the thin capillary network to reach the undersurface of the skin, clumping there and presenting themselves as circular reddish bumps on the surface of the skin. Among granuloma annulare causes, association with some other autoimmune disorders is identified such as lupus erythematosis, addison’s disease and rheumatoid arthritis. It may also occur as a result of hypersensitivity to wheat gluten, tetanus vaccine or copper and infections along with animal, insect bites and sunlight exposure.


This condition is more common in females than males. It affects individual in all age groups however relatively rare in infants. Granuloma annulare symptoms begin in the form of small pimple like bump which advances rapidly to large and large sized lesions. Patient notices the appearance of thickened plaques, red in color, firm in consistency on the surface of forearms, hands and feet. There may be multiple rings which merge to form a large single annular plaque. It may present in four different varieties: localized, generalized, subcutaneous and perforating. It may sometimes also present on the circumference of the waist and sides and continues for years without any therapy.


Granuloma annulare diagnosis is based upon the physical examination of the bumps by a skin doctor. Biopsy can be performed in order to comfirm the diagnosis or differentiate the condition from other skin disorders and malignancies.


In most cases treatment of granuloma annulare is not needed because these lesions have the tendency of spontaneous resolution within a period of few months to few years. However the process of self-healing can be quickened by the adequate treatment options. Granuloma annulare treatment includes corticosteroids creams and ointments, adhesive patches or bandages for improved rapid results, direct injection of corticosteroids in the papules, liquid nitrogen cryotherapy to remove the lesion and replacement of it by new normal skin, laser and light therapy or excision of the lesion. All these are associated with side-effects and post-surgical pain. Oral medications are prescribed to prevent reactions of immune system. Granuloma annulare herbal product is effective in timely removal of these lesions without any side-effects and pain as seen with allopathic medications and surgical procedure. The herbal mixture improves the overall appearance of skin, leaving it smooth and soft along with completely curing this ailment in no time.