What is Grave’s disease? is an autoimmune disorder of thyroid gland characterized by overproduction of thyroid hormones in the body hence hyperthyroidism results. Abnormal immune cells called autoantibodies are present and circulate in the blood. Thyroid stimulating immunoglobulins (TSI’S) bind to thyroid hormone receptors and stimulate them resulting in over-activity of the gland and hyperplasia of the thyroglobulin in thyroid follicles, which increases the production and release of thyroid hormones, thyroxine and tri-iodothyronine. Thyroid hormones are responsible for many normal metabolic functions of the body hence their increase leads to serious metabolic complications which may prove fatal if not treated and controlled in time.
Graves’ ophthalmopathy frequently show at the similar time as hyperthyroidism or several months later. other than signs and symptoms of ophthalmopathy might appear years before or after the onset of hyperthyroidism. Graves’ ophthalmopathy can occur too even if there’s no hyperthyroidism.
GRAVE’S DISEASE CAUSES:
Grave’s disease causes occur as a result of imbalanced disease-regulating immune system of the body. Exact cause of immune system dysfunction and aberrant antibodies is not known but several factors are responsible for the disease’s origin and associated reactions. Hereditary factor is dominant in most cases. These abnormal antibodies mimic thyroid stimulating hormone (TSH) in function hence stimulating thyroid gland to release a large amount of thyroxine (T4) and tri-iodothyronine (T3) in blood. This causes the thyroid gland to increase in size accordingly. This elevated hormonal release affects the major systems of the body such as heart, circulation, nervous system and skin. Disturbances in the body temperature, menstrual cycles and body’s muscles play a prominent role in occurrence of grave’s disease.
GRAVE’S DISEASE SYMTOMS:
Most common in women over the age of 20 years but it can occur in any age and can affect men too. Most women are affected immediately after childbirth. Grave’s disease is associated with multiple organs dysfunctions in the body. Prominent swelling in the neck due to thyroid enlargement (goiter) and pretibial myxedema constitutes an important manifestation of Graves’ disease symptoms. Bulging out of eyes (exophthalmos) is prominent indication of thyroid hormones excess. Anxiety, psychosis, mania, irritability, insomnia, fatigue and tremors are commonly seen. Weight loss despite of heavy eating, loss of libido, heat intolerance, excessive sweating diarrhea, abnormality in bowel habits, alterations in menstrual cycles, erectile dysfunction, reddish thick skin all result due to abnormal metabolic effects produced by surge of thyroid hormones in the body. Cardiac pathologies present as arrhythmias, sinus tachycardia, atrial fibrillations, hypertension and premature ventricular contractions.
GRAVE’S DISEASE DIAGNOSIS:
It is diagnosed in accordance to its clinical manifestations. Two important signs of Grave’s disease diagnosis are exophthalmia and non-pitting edema (pretibial myxedema). Enlarged goiter can been visualized by naked eye or by phsycial examination but can be seen by ultrasound of thyroid and CT scan as well. Thyroid hormones in blood are serologically measured.
GRAVE’S DISEASE TREATMENT:
Grave’s disease treatment options include anti-thyroid drugs, surgical excision of thyroid gland (thyroidectomy) and radioactive iodine. Agranulocytosis is a fatal side-effect of anti-thyroid agents which makes the patient immune-compromised and susceptible to infections. Radioactive iodine is a slow treatment option and does not lead to complete cure. Its side effects include hypothyroidism. Grave’s disease herbal product is not associated with any such risks of therapy and helps in complete cure of the condition through the advantageous effects of its herbal mixture. It combats effectively against its symptoms without harming any other organs of the body.