Archives

Myasthenia gravis – a neuromuscular disorder

What is myasthenia gravis?

It is a neuromuscular disease, sometimes also known as goldflam disease. The voluntary muscles are affected and will become weak and will also easily fatigue. This happens due to defective nerve signal transmission leading to defective muscle contraction. The periorbital muscles are usually affected in the initial stage leading to ptosis and diplopia. Involuntary muscles are spared from the effects of this disease. Myasthenia gravis herbal product by natural herbs clinic is the recommended treatment.

Myasthenia gravis cause:

nerves ends at muscle fibers forming neuromuscular junction. Here signals are transmitted from nerves to the muscle fibers by the release of neurotransmitter vesicles, from the nerve endings in post synaptic cleft. This neurotransmitter then stimulates muscle fibers by binding with post synaptic acetylcholine receptors. During ocular myasthenia gravis these receptors are destroyed by auto antibodies produced by body’s own immune system. The exact trigger of immune system is not known even by the experts at natural herbs clinic but abnormally functioning thymus is the most suspected myasthenia gravis cause.

Myasthenia gravis symptom:

the main myasthenia gravis symptom as observed by experts at natural herbs clinic is muscle weakness however the severity of this weakness varies. In most cases symptoms are localized in initial stage but will progress to generalized forms in later stages. The first noticed symptom is patient’s susceptibility to fatigue where muscles become weak in a progressive manner during the period of activity while the condition tends to improve after rest. When only ocular muscles are affected which happens in only 15% of patients, it is tagged as ocular myasthenia. When facial muscles get involved, symptoms such as dysarthria, dysphagia, difficulty in chewing and development of weird facial expressions are seen. When limb muscles are affected simple activities such as walking, lifting things become a problem.

Myasthenia gravis diagnosis:

myasthenia gravis patient have some distinguishing complains on examination this include progressive muscle weakness from the start of day which improves by resting, impaired eye movements and muscle weakness which is not associated with loss of ability to feel. Myasthenia gravis diagnosis can be confirmed by several tests this includes edrophonium test, blood test, repetitive nerve stimulation test, single fiber EMG, chest X-rays, CT, pulmonary function test and muscle biopsy.

Myasthenia gravis treatment:

myasthenia gravis treatment is done to achieve two goals first increase nerve muscle signal transduction and second combat the triggered autoimmune reaction. Myasthenia gravis herbal product by natural herbs clinic is the product which have potential to treat myasthenia in both ways and improves the prognosis of the disease.

Myasthenia gravis complication:

three main complications are observed in such patients first myasthenia crisis second aspiration pneumonia due to poor functioning oropharyngeal muscles and cholinergic crisis which is a consequence of cholinesterase treatment. Respiratory failure showing the involvement of respiratory muscles is usually the end stage complication. Pneumonia in such cases leads to death and it is caused due to inability to cough by such individuals. Hypoxemia and respiratory acidosis might leave the patient somnolent.

Myasthenia Gravis Treatment, Causes, Symptoms, Diagnosis

Myasthenia gravis is a chronic neuromuscular autoimmune disorder of muscles and the nerves which are supplying them. Muscle weakness and fatigue are prominent features. Rapid muscle fatigue occurs as a result of autoantibodies created against acetylcholine receptors at postsynaptic neuromuscular junctions. Excitatory effect of acetylcholine is thus blocked at these junctions leading to progressive muscular weakness. Varying degrees of voluntary skeletal muscles weakness are present in the patients.

Ocular myasthenia gravis:

Ocular myasthenia gravis is another type of myasthenia gravis (MG) in which the muscles that progress the eyes and handle the eyelids are easily fatigued and weakened.

  • MYASTHENIA GRAVIS CAUSES:

It can affect an individual of any age however it most commonly affects the women below 40 and older men above 60 years of age. This disease is neither directly inherited nor is it contagious. Myasthenia gravis causes features the imperfection or miscommunication between the muscles and the nerves that are supplying it. Muscle contraction is brought about by binding of acetylcholine (Ach) at neuromuscular junctions. Sometime incorrect instructions by the body’s thymus gland leads to development of defective immune cells called autoantibodies which act against the body’s own Ach receptors ultimately altering or destroying them preventing the normal muscles to contract effectively.

  • MYASTHENIA GRAVIS SYMPTOMS:

Myasthenia gravis symptoms are produced as a result of faulty and inadequate contraction of voluntary muscle group (skeletal muscles). Onset may be sudden and not recognized immediately as myasthenia gravis. Damage to ocular muscles manifest as drooping of eyelids (ptosis) and blurring of vision. In face and throat muscle, patient experiences difficulty in speaking, chewing, swallowing along with abnormal facial expressions. Patient may choke or gag as a result of weak pharyngeal muscles. In chest, breathing difficulties result. Weakness in arms, hands, fingers, neck and legs is felt. Person waddles when walk due to leg muscle weakness. Sometimes it becomes very difficult for the patient to hold up his head as a result of weakening of muscles in the neck.

  • MYASTHENIA GRAVIS DIAGNOSIS:

The important signs and symptom experienced by the patient helps in early Myasthenia Gravis diagnosis and treatment. Medical history along with adequate physical and neurological examinations is carried out. Special blood tests reveal Ach autoantibodies in the circulating blood. Edrophonium test using intravenous injection of edrophonium chloride briefly corrects muscle weakness hence an important diagnostic test. Impaired nerve-muscle transmission is diagnosed by single fibre electromyography. X-ray chest, CT and MRI should be done for presence and identification of thymoma.

  • MYASTHENIA GRAVIS TREATMENT:

No complete cure is yet present but it is an effectively manageable condition. Myasthenia gravis treatment is based on its control. Anticholinestrase agents such as neostigmine and physostigmine are prescribed to improve muscle strengths. Immunosuppressants are given to lower antibodies level thus improving muscle functions but it is associated with great amounts of side-effects and risk. Thymectomy is performed to surgically remove thymus in advanced uncontrollable cases or if a tumor of thymus is present. Myasthenia gravis herbal product, made up of pure natural herbs, helps to fight fatigue and immensely improves other associated symptoms. There are no size-effects of this herbal product. It also prevents the patient from going through painful surgical operation of thymus removal by efficiently controlling and curing the disease. The herbal mixture improves the neuromuscular transmission and serves as an amazing treatment for this ailment.