Archives

Polycythemia vera: disorder of the bone marrow

Polycythemia Vera is a ceaseless dynamic myeloproliferative neoplasm (MPN) basically characterized by an elevation of the red platelets. Patients might also have a white platelet check, a lifted platelet number, and an expanded spleen.

Polycythemia Vera d

In 2005, it was found that 95% of patients with Polycythemia Vera have a transformation in the JAK2 quality. This quality assumes a huge part in the generation of red platelets (notwithstanding white platelets and platelets). At the point when the quality is transformed (JAK2 V617F), there is lost ordinary regulation, and an overproduction of red platelets, and on occasion, blood cells and platelets. The revelation of this change moved a wide scope of exploratory tasks which will ideally bring about new and viable medicines for PV and the other myeloproliferative neoplasms.

Polycythemia Vera Symptom:

Polycythemia Symptoms incorporate side effects identified with inordinate thickening of the blood, for example, reddened face, bleeding of the gums, dizziness, and irritation. Polycythemia can also influence the eyes and ears, prompting obscured vision or tinnitus. In more genuine instances of polycythemia, thrombosis (thickening) can create, prompting heart assault or stroke.

  • Headache
  • Sweating
  • Ringing in the ears
  • Blurred vision or blind sides
  • Dizziness or vertigo
  • Reddish skin
  • Unexpected weight reduction
  • Bleeding or coagulating
  • Early sentiment completion
  • Itching, particularly after the shower
  • Burning and redness of the hands or feet
  • Tiredness
  • Night sweats
  • Bone agony

Now and again, the complexities of polycythemia, including heart attack and stroke, can be life threatening.

Polycythemia Vera Causes:

The Polycythemia Vera Causes is still obscure. The issue is typically contracted at the same time, in uncommon cases, it can be acquired. It is regularly characterized by an increment in the generation of red platelets. Patients with PV are regularly manifestation free at the season of conclusion.

Polycythemia Vera Treatment:Polycythemia-Vera-228x228

The objective of Polycythemia Vera Treatment is to decrease the thickness of the blood and forestall draining and thickening.

A strategy called phlebotomy is utilized to diminishing blood thickness. One unit of blood (around 1 half quart) is evacuated week by week until the hematocrit level is under 45 males or 42 females. At that point treatment is preceded as required.

Incidentally, chemotherapy (particularly hydroxyurea) may be given to diminish the quantity of red platelets made by the bone marrow. Interferon might also be given to lower blood numbers. A medicine called anagrelide may be given to lower platelet counts.

A few patients are encouraged to take aspirin to reduce the danger of blood clots; however it builds the danger for stomach dying. UltravioletB- light treatment can diminish the serious itching some patient’s experience.

For further detail visit Natural Herbs Clinic.

Advertisements

Polycythemia Vera- caused by hyperplastic bone marrow

What is Polycythemia Vera?

A condition characterized by increased number of circulating red blood cells leading to hyper viscous blood due to bone marrow hyperplasia knowns what is polycythemia vera. It normally also cause increased number of other cell types that is white blood cells and platelets. Without treatment the condition can lead to life threatening complications. Polycythemia Vera herbal product by natural herbs clinic is the treatment available for the management of this condition.

Polycythaemia rubra Vera:

Polycythaemia rubra Vera is the most familiar of primary polycythaemia. Polycythaemia rubra vera is reason by somatic alteration in a single haematopoietic stem cell.

Polycythemia Vera epidemiology:

The disease is quit uncommon effecting 0.1 – 1.6 person per million. The disease commonly effects individuals over the age of 50 – 70 years but can affect those in there early adult or childhood ages.

Polycythemia Vera causes:

The disease is caused due to mutation in the gene which is responsible for the production of JAK 2 protein. This mutation causes abnormal proliferation of bone marrow cells which leads to increased cell production. Researchers at natural herbs clinic and other institutes found that the mutation normally occur after birth so the condition is acquired, rather than inherited. Males are more commonly affected then females.

Polycythemia Vera symptoms:

The polycythemia symptoms due to hyperviscosity of blood include breathing difficulty when lying down, dizziness, excessive bleeding, fullness in the left upper abdomen (due to enlarged spleen), headache, itching especially after a warm bath, red coloring, especially of the face, shortness of breath and symptoms of phlebitis. Other symptoms that can also be present in some individuals are cyanosis, fatigue, red spots on skin and vision problems as observed by experts at natural herbs clinic.

Polycythemia vera diagnosis:

The polycythemia vera diagnosis is done on the basis of bone marrow biopsy, complete blood count with differential, comprehensive metabolic panel, erythropoietin level, genetic test for the JAK2V617F mutation, oxygen saturation of the blood, red blood cell mass, vitamin B12 level, ESR, lactate dehydrogenase test, leukocyte alkaline phosphatase, platelet aggregation test and serum uric acid test. The blood test will show elevated hematocrit, hemoglobin and erythropoietin level. Hyperplasia of the bone marrow cells will be observed on biopsy while gene mutation test will confirm the presence of the disease.

Polycythemia Vera treatment:

The polycythemia Vera treatment is directed toward reduction of blood thickness and prevention of clotting. Phlebotomy is the procedure normally performed in hospital environment in which 1 pint blood is removed per week until the hematocrit level comes to normal. A better remedy to combat with this problem is polycythemia Vera herbal product by natural herbs clinic which is made of natural ingredients and will treat your condition at home.

Polycythemia Vera complications:

the polycythemia vera complications includes formation of blood clots which can lead to pulmonary embolism and deep venous thrombosis, spleenomegaly, skin problems such as itching and life threatening blood disorders such as myelofibrosis, myelodysplastic syndrome and acute myelogenous leukemia.

Polycethemia Vera prognosis:

As the condition is chronic and takes several years to develop its accidental diagnosis is common and with the timely treatment both development of complications and progression of the symptoms can be stopped.

Polycythemia Vera Treatment, Causes, Symptoms, Diagnosis

Polycythemia vera is a type of myelopoliferative blood disorder characterized by the excessive formation of red blood cells (erythrocytes) by the bone marrow. White blood cells and platelet count also increases. It is a rare bone marrow disorder. Primary disease manifestation lies in the thickening of blood caused by too many red blood cells in the circulation which might lead to clot formation. Clot formation causes the blockage of arteries and veins ultimately leading to fatal stroke or a heart attack. Due to increase density of blood in the vessels, the flow becomes slow and sluggish preventing adequate oxygen from reaching the tissues especially heart hence angina or heart failure results.

POLYCYTHEMIA VERA CAUSES: 

It affects all age group although incidence rises with age. It occurs more commonly in men than women. Polycythemia vera causes is associated with the genetic mutation of an important gene called JAK2V617F. The exact cause of mutation is not known. A single faulty haematopoietic precursor cell in bone marrow leads to clonal expansion resulting in polycythemia vera. The sensitivity of erythroid precursors to erythropoietin increases causing large production of red blood cell formation.

Polycythemia Rubra Vera:

Polycythaemia Rubra Vera, also called essential polycythaemia Vera, is an problem where an excess of red cells are produced in the bone marrow, with no certain cause.

Polycythemia Vera life expectancy:

Polycythemia Vera life expectancy may be bargained as the infection develops to myelofibrosis, or seldom, intense leukemia.

POLYCYTHEMIA VERA SYMPTOMS:

The disease is slow and progressive usually requiring the period of about 4 to 5 years before it presents itself. Characteristic signs and polycythemia vera symptoms include increased mass of erythrocytes (RBCs), neutrophilia (increased neutrophils than normal), thrombocytosis (increased platelet count in blood) and splenomegaly (enlargement of spleen). Severe burning and itching of hands and feet is found due to histamine release. Increased viscosity of blood is responsible for the following symptoms: history of vascular occlusive disease, dizziness, headache, gout, pruritus, mental confusion, flushed face and abdominal discomfort. Due to abnormalities of RBCs and platelet, symptoms of epistaxis, thromboembolism, gum bleeding and gastrointestinal bleeding is common.

POLYCYTHEMIA VERA COMPLICATIONS:

Other than stroke and heart attack being a fatal polycythemia vera complications, a small group of sufferers progressively develop malignant blood disorders of acute myelogenous leukemia or myelofibrosis.

POLYCYTHEMIA VERA DIAGNOSIS:

Prognosis of the disease is strongly influenced by early diagnosis and treatment. Blood tests are performed to find out the count of cells. Complete blood picture and erythrocyte-sedimentation rate reveal and confirm the polycythemia vera diagnosis. Physical examination reveals enlarged spleen or liver and in some cases gouty nodules.

POLYCYTHEMIA VERA TREATMENT:

Polycythemia vera treatment is based upon reducing the symptoms of the disease because no specific cure is present for it. Timely management is necessary otherwise it may prove fatal. Phlebotomy is performed to remove blood from the body thus reducing the viscosity of blood associated with increased volume. Aspirin is also prescribed to prevent clot formation. Chemotherapy is indicated for its treatment but it is associated with increased risk of developing acute myelogenous leukemia. Radioactive isotopic injections, although suppress bone marrow, can also lead to AML malignant transformation. Polycythemia vera herbal product cures the condition effectively owing to the presence of its herbal constituents which help the body to restore and maintain its normal physiological functions by completely treating the disease and its associated symptoms in a short span of time.